Contemporary Understanding and Management of Cerebral Vasospasm (A Practical Guide)

by Gilmore Emily J, Bulsara Ketan R
9789351525608

Contemporary Understanding and Management of Cerebral Vasospasm: A Practical Guide is written by clinicians, for clinicians to provide real-world information based on our current understanding of the disorder with the hope that it will lay the foundation for optimizing treatments across the world. For the first time, under one cover you can explore the history and epidemiology of this process. Systematically, the editors have examined the rational research that defines a cascade of molecular and inflammatory events leading not to a simple reversible vasospasm phenomenon, but indeed a progressive arteriopathy. As in most human diseases, animal models are imperfect and although inhibitors of potent vasoconstrictors such as endothelin-1 (ET-1) and antagonism of inflammatory inhibitors of the natural vasodilator, nitric oxide (NO) are effective in animal models, they have fallen short in human trials. The molecular mechanisms chapter in this volume outlines exciting and promising new molecules and one may be tempted to wait for the magic bullet. However, the editors, instead, take all the successes and failures of past therapy and provide in the appendix a carefully thought out protocol for today’s SAH patient. It is detailed and represents the best of a modern neurointensive approach to quality patient care.

 

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